You can only cash in on a winning combination when it appears on a payline that you have personally enabled. And enabling these paylines is easy; you do it right before you spin by using the controls at the bottom left hand side of the Lizard Lounge interface. The winning combinations, by the way, must read from left to right or they are not valid. For example, if you have a "Cocktail" symbol on reels 1, 2 and 3 you can be winner of the "3 Symbol" payout. However, if those symbols are on reels 2,3 and 5 you do not win.
Also, if there is more than one conceivable winning combination on a particular payline, only the highest winning combination will be paid. Scatter wins and bonus win are exceptions to this.
Regular Payout Schedule
As far as the "regular" symbols in this game are concerned, six of them will bring at least 250 coins if you are able to get five on an enabled payline.
Here are the regular symbols for the game, with the payout for hitting five of them on an enabled payline:
Party Girl (500)
Disco Ball (350)
Ugly Watch (300)
Money Clip (220)
Four Pepper Spray Girls (wilds) on an enabled payline brings 350 coins. Five of them will bring 2500. The scatter symbol (the Disco) pays less, but it can appear anywhere on the five reels, so the rule about enabled paylines doesn't apply. Five scatter symbols, anywhere on the reels, pays 120 coins.